Roles of 3D genome organization in cell differentiation and embryonic
We are interested to learn to what extent changes in 3D genome folding facilitate changes in cell fate during development, using both fly and mouse development as a model system. In Drosophila, distinct levels of 3 posterior Hox genes specify the anterior-posterior cell identities in the 10 most posterior segments of the animal. The three genes are positioned next to … Continue reading Roles of 3D genome organization in cell differentiation and embryonic
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