Category Archives: Conference Notes

Trail membrane ligand induces apoptosis to neighbor cells. many individuals not responsive to trail therapy to kill cancer. cell to cell variability. caspace signaling part of kill signal waiting delay varies dramatically. Distribution depends on dose. time to die post … Continue reading →

Alexander Hoffmann, University of California, San Diego, Parsimonious Gene Regulatory Network modeling reveals mRNA half-life control of the pathogen-responsive transcriptome innate immune response info processing decompose into modules. combinatorial code encoded by signal pathway, decoded by TFs combos on promoters. signaling … Continue reading →

Nicole King, University of California, Berkeley, The origin of animal multicellularity Many of the genes for cell adhesion and cell-cell signaling evolved before the transition to multicellularity. Originally involved in capturing prey? Now in holding cells together? Colony formation: single cell … Continue reading →

Reka Albert, Pennsylvania State University, Discrete dynamic modeling of signal transduction networks Discrete dynamic modeling: boolean, arbitrary choice for times — sync update, random update, explicit delay update. Drought signaling in plants to change stomata size (via abscisic acid signaling) variability … Continue reading →

Uri Alon Linear relations between quantitative traits. tradeoffs between tasks (e.g. teeth for meat or plants, toes for walking or grasping) metric decrease in distance space results in linear arrangement.  (for the right choice of coordinate scale, [may be log]). … Continue reading →

Dennis bray Flagella motor switching. Conformational spread of motor FLiM proteins based on cheY binding. Determine clockwise v counterclockwise. Experiments show stall, switch time etc. Receptor lattice model Dense cells move to cold. Most cells move to heat. Growing cells … Continue reading →

Title: Unique features of metazoan gene regulation provide robust cell fate decisions from stochastic components. Alistair N Boettiger, Jacques Bothma, Michael Perry, Michael Levine Abstract: The developmental patterning of multicellular organisms requires precise control on the scale of microns and … Continue reading →

Short Abstract — It has been shown that strong gene induction in eukaryotic cells leads to large bursts of gene expression – increasing total mRNA synthesis at the cost of substantially elevating cell-cell variation in expression levels.  We investigate how … Continue reading →