| 7:30 pm – 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm – 9:30 pm | Are there principles of noise and networks in biology? |
| Discussion Leader: Hong Qian (University of Washington) | |
| 7:40 pm – 8:10 pm | Alex van Oudenaarden (MIT) “Controlling Gene Expression Fluctuations During Development” |
| 8:10 pm – 8:15 pm | Discussion |
| 8:15 pm – 8:45 pm | Kim Sneppen (Niehls Bohr, Denmark) “Biological Network Components” |
| 8:45 pm – 8:55 pm | Discussion |
| 8:55 pm – 9:25 pm | George Oster (UC Berkeley) “Neural Networks Pattern Shells” |
| 9:25 pm – 9:30 pm | Discussion |
Day 1: stochastic physics in biology Gordon conference
Opening talks:
van Oudenaarden.
- pt1: Multiple inputs into end1 (skn-1,med1/2, end3) provide robustly above threshold amounts of signal. Near threshold signaling results in some cells (and thus some embryos) failing to latch on auto-activation.
- pt2: miRNA damping fluctuations: removing lin4 (miRNA) results in oscillations in mRNA levels of lin14. lin4 promoter also oscillates like14, couple oscillating repressor provides damping.
Kim Steppen: modeling lambda with simple 3 component systems, with ODEs and stochastic simulation.
George Oster stands in for Adam Arkin and talks about shell patterning.
post-talk discussion with Weinberger and van Oudernaarden