Journal Club 08/11/14

Presented by Shu

Mapping Brain with Diffuse Optics

  • Optical methods as alternative to MRI or PET (which are not electronic embedded device compatable, e.g. parkinson’s deep brain stimulator or pacemakers or young children).
  • Compare IR specta at 750 and 860, distinguish oxygenated vs. deoxygenated hemoglobin (Onaral lab, Drexel)
  • measure backscattered light in these wavelengths
  • penetration depth of up to 1 cm into brain regions.
  • limitations
    • tradeoff in head coverage vs. spatial resolution
    • sensitive to haemodynamics in superficial tissue (e.g. scalp / non-brain activity)
    • no structural information (shape of head, where photons came from).

setup details

  • usse fMRI to generate head model. (get head shape).
  • 96 sources and 92 detectors -> 1200 usuable source detector pairs.

comparison to fMRI

  • see pretty good correlation with fMRI and known brain region – function correlations.
  • e.g. audio processing, visual processing etc.
  • can correlate activity from different brain regions to pull out connectivity.
  • analyzed in resting state networks — just getting correlated connectivity, not necessarily progressive transforms of thought.
  • some subjects show better and worse correlation to fMRI
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