Notes
Linda Partridge, (U College London) Aging Flies
Insulin signalling
Increased autophagy,
reduced diet. Yeast component matters more than sugar. Not calories. AA necessary for fecundity and lifespan. Met essential for fecundity, still allows long life. Propose nutrient imbalance shortens life.
FOXO in insulin/ TOR
remove, shorten life, more ddt sensitive, stop insulin mutant lifespan increase.
increase antibiotic resistance correlates with lifespan.
Paul Garrity (Brandeis). Temperature variation and sensing
Thermosensing in larvae
dTrpA1 sufficient to disorient
Adults still avoid high temp but choose wide range of medium temps.
overexpress, heat flies, seizure.
mojv 31C threshold instead of 27.4. Naturally choose these temps
electophile sensing by TRPA1 in mammals and flies. mosquito’s don’t like wasabi.
Electrophiles are dna protein toxic. Toxin not actually made until ground.
Brian Lazzaro (Cornell) Pleiotropy and immunity
Mating decreases infection survival.
immune system is less induced. Requires germline.
High sugar diet very susceptible, high protein less susceptible.
Response varies with genotype.
Lawrence Goldstein (UCSD) Alzhiemers and vesicle movement
Tau genetically linked to alzhiemers.
effects axonal transport
if cell body was 20ft, axon 200mi. Transit takes 10 days. Axons can block up and die.
Too much app blocks axons. Not the amyloid peptide part but the c-term matters.
Homo nulls seriously dead. Use hets, track 32000 vesicles. Multiple modal velocities. Fast modes faster than in vivo rates.
Kinesen is less processive in vivo does fall off more, more molecules, falls off less.
Gsk3 and app proteases effect transport speed not number of attached motors.
Wittkopp (U Michigan): Polymorphism and Divergence
Pigment polymorphisms
Virilis group novaamexicana and Americana. .4mi yrs apart. Crossable.
5 discrete intermediate classes.
Difference is in myna levels of tan vs ebony.
Cis reg changes in ebony.
Igor Zhimulev (Novosibirsk, Russia) Chromatin organization.
previously unable to precisely map polythene bands.
chriz protein found in interbands but not puffs. H1 dips, nucleosomes dip, but structured. Interbands can physically stretch, bands stay compact.