Sleep clears metabolites from the adult brain
Colenso lab journal club
- Consensus that sleep is restorative, little mechanistic understanding of why.
- Lymphatic systems does not extend into CNS / brain. (in other part of the body used to clear fluid)
- spinal fluid flows around the space around the arteries in the brain.
- Observer much more diffusive flow into the brain during sleep than during awake.
- Interstitial space increases during sleep or anesthesia, allowing more flow.
- Mediated by osmotically triggered change in cell size. – transfers water from the artery into the interstial space.
- block arrousal by blocking adrenergic signaling in awake animals.