Monthly Archives: March 2011

platform sessions 03/31/11

Posted on March 31, 2011 by admin

Jerome Cartry (Bodmer lab, Sanford-Burnham) Let7 miRNA knockouts have cardiac arrhythmia. 3 target genes change expression levels. Wan Yoon (Montell Lab, Hopkins) Mir279 loss of function leads to extra border cells, similar to extra jak/stat signaling.

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Plenary Sessions, Thursday 03/31/11

Posted on March 31, 2011 by admin

Notes Linda Partridge, (U College London) Aging Flies Insulin signalling Increased autophagy, reduced diet. Yeast component matters more than sugar. Not calories. AA necessary for fecundity and lifespan. Met essential for fecundity, still allows long life. Propose nutrient imbalance shortens … Continue reading →

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Wednesday 03/30/11

Posted on March 30, 2011 by admin

Fly Meeting: Larry Sander Lecture Pain response hypersensitivity (in healing) – nociception can become chronic (fibromyalgia, cancer arthritis) Allodynia (respond to previously non-irritant stimuli) hyperalgsia respond more seriously to minor irritant dronc activity (cell death response) is required for allodynia. … Continue reading →

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Tuesday 03/28/11

Posted on March 29, 2011 by admin

10:00 A — 7:10 P, 7:45 — 11:30P Prep for lab meeting. Find high resolution image of promoter deactivation at mitotic wave and promoter reactivation. observe: Degenhardt et al (Cell 2009) retracted. Practice talk. Fixing slides to respond to feedback. … Continue reading →

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Protected: enhancer gradient analysis (hb + sna)

Posted on March 29, 2011 by admin

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Monday 03/28/11

Posted on March 28, 2011 by admin

10:30 A – 7:00P, 7:40P — 10:00P Finish confocal run.  Not long enough warm up — all images after 1 have very dramatic drift.  Try again tonight. Incorporate results from talk into lab meeting — might need to give presentations in … Continue reading →

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Protected: multipart transcription foci

Posted on March 27, 2011 by admin

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Sunday 03/27/11

Posted on March 27, 2011 by admin

5:00 P — 8:00 P Letters to Boston for postdoc interviews. Confocal, MP01.  chose 11 embryos, started lens-warmup at 6:05p.  Start scan 6:50.  50 sections, 300 nm intervals. Analysis of MP10 d and e data sets and MP05 data (need … Continue reading →

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Transcription modeling

Posted on March 27, 2011 by admin

Some thoughts on simple transcription models. Best case: noise is Poisson — limited only by the arrival of a single rate limiting component.  This allows for only linear control: doubling activator doubles arrival rate of transcription machinery. Adding opening and … Continue reading →

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Saturday, 03/26/11

Posted on March 26, 2011 by admin

11:00 A – 8:30 P Upgrade computer RAM to 16GB. hb gradient analysis, finalize first version of slides for Fly Meeting, organizing slides for lab meeting playing with transcription models.

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